Subway ranks as the largest U.S. restaurant brand with 24,772 domestic locations and as the second largest in terms of U.S. systemwide sales behind McDonald’s with $11.4 billion. The rapidly growing quick-service sandwich brand is owned by privately held Doctor’s Associates Inc., based in Milford, Conn. The company is 100-percent franchised, and its franchisees have opened more than 38,000 locations in 98 countries since the chain was founded in 1965.